A clinical study on 33 cases of idiopathic thrombocytopenic purpura who had admitted to the Department of Internal Medicine Keimyung University Dongsan Medical Center from January 1988 to December 1991.
The median age of the patients was 37.3 years and female prevalence was noted (female to male ratio 2.3: 1)
The peripheral blood picture revealed anemia in 14 cases, moderate to severe thrombocytopenia(<50,000/㎣) in 28 cases.
The positive antinucler antibody test was observed in 3 cases and the anti-platelet antibody was positive in 9 cases of the 18 cases who were performed the test.
The bone marrow studies revealed normocellular marrow in 29 cases, increased megakaryocyte counts in 19 cases and most of them were immature from.
The prednisone was administered in 30 cases: complete remission was achieved in 11 cases and partial remission in 16 cases, but only 3 cases are achieved persistent remission.
Persistent remission was achieved in most of cases(83%) who was undergone splenectomy and in 13 cases treated with IV immunoglobulin, remissions were achieved in 8 cases, but the response was transient.
The complications of the treatment were observed as follows:
a. 1 patient was dead because of pneumonia with sepsis, 1 cases of pulmonary tuberculosis and 1 cases of peptic ulcer bleeding were observed in prednisone group.
b. among the splenectomy group, 1 patient died because of subphrenic abscess with sepiss.
c. Severs headache and anaphylaxis occurred in a case of the immunoglbulin treatment group and peripheral neuropathy was obsered in all cases of the vincristine group.
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